Tumor Recurrence After Complete Resection for Non-Small Cell Lung Cancer

医学 淋巴血管侵犯 围手术期 危险系数 比例危险模型 肺癌 阶段(地层学) 原发性肿瘤 回顾性队列研究 T级 外科 癌症 内科学 转移 置信区间 古生物学 生物
作者
Matthew D. Taylor,Alykhan S. Nagji,Castigliano M. Bhamidipati,Nicholas Theodosakis,Benjamin D. Kozower,Christine L. Lau,David R. Jones
出处
期刊:The Annals of Thoracic Surgery [Elsevier BV]
卷期号:93 (6): 1813-1821 被引量:186
标识
DOI:10.1016/j.athoracsur.2012.03.031
摘要

Long-term survival after R0 resection for non-small cell lung cancer (NSCLC) is less than 50%. The majority of mortality after resection is related to tumor recurrence. The purpose of this study was to identify independent perioperative and pathologic variables that are associated with NSCLC recurrence after complete surgical resection.A retrospective examination was performed of a prospectively maintained database of patients who underwent resection for NSCLC from July 1999 to August 2008 at a single institution. Clinicopathologic variables were evaluated for their influence on time to recurrence. Cox's proportional regression hazard model examined the association of recurrence in NSCLC.A total of 1,143 patients met inclusion criteria and had complete follow-up information. Of these patients, 378 (33.1%) had recurrence of the primary cancer. Median follow-up was 24 months (range, 3-134 months). Preoperative tumor maximum standardized uptake value (SUVmax) greater than 5 was associated with increased risk of recurrence (hazard ratio [HR], 1.81; p=0.01). Preoperative radiation was independently associated with recurrence (HR, 1.98; p=0.05) as well as the presence of pathologic stage II and stage III disease (stage II: HR, 2.53; p=0.05; stage III: HR, 6.49; p=0.006). Subgroup analysis found that sublobar resection was also associated with locoregional recurrence after resection (HR, 4.17; p=0.02) and lymphovascular invasion of distant recurrence (HR, 4.21; p=0.002).In the largest series reported to date on postresectional recurrence of NSCLC, SUVmax greater than 5, increasing pathologic stage, and the administration of preoperative radiation were independently associated with NSCLC recurrence after resection. Sublobar resection was independently associated with locoregional recurrence, and lymphovascular invasion was associated with distant recurrence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Passskd完成签到,获得积分10
1秒前
fang应助科研通管家采纳,获得10
2秒前
山野村夫应助科研通管家采纳,获得10
2秒前
爆米花应助科研通管家采纳,获得10
2秒前
予修应助科研通管家采纳,获得10
2秒前
liliflower应助科研通管家采纳,获得10
2秒前
伶俐乐菱应助科研通管家采纳,获得10
2秒前
伶俐乐菱应助科研通管家采纳,获得10
2秒前
FAN应助科研通管家采纳,获得10
2秒前
FashionBoy应助科研通管家采纳,获得10
2秒前
天天快乐应助科研通管家采纳,获得10
2秒前
FAN应助科研通管家采纳,获得10
2秒前
2秒前
李治海发布了新的文献求助10
3秒前
zhuzhu完成签到,获得积分10
4秒前
星辰大海应助jiaolulu采纳,获得10
4秒前
5秒前
颖宝老公完成签到,获得积分0
5秒前
清爽夜雪完成签到,获得积分0
6秒前
量子星尘发布了新的文献求助10
6秒前
大翟完成签到,获得积分10
8秒前
不远完成签到,获得积分10
9秒前
冯珂完成签到 ,获得积分10
11秒前
Graham完成签到,获得积分10
11秒前
稳重乌冬面完成签到 ,获得积分10
13秒前
一苇以航完成签到 ,获得积分10
14秒前
戚雅柔完成签到 ,获得积分10
14秒前
vsvsgo完成签到,获得积分10
15秒前
米奇完成签到 ,获得积分10
15秒前
加一点荒谬完成签到,获得积分10
15秒前
15秒前
一一一给轻松白桃的求助进行了留言
17秒前
zz2905完成签到,获得积分10
17秒前
小超人完成签到 ,获得积分10
18秒前
香蕉初瑶完成签到,获得积分10
18秒前
meimei完成签到 ,获得积分10
18秒前
儒雅的菠萝吹雪完成签到,获得积分10
19秒前
19秒前
20秒前
水寒完成签到,获得积分10
20秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022