Polyoxometalates as Inhibitors of the Aggregation of Amyloid β Peptides Associated with Alzheimer’s Disease

Inorganic amyloid inhibitors: Four types of polyoxometalates (POMs) were found to be efficient inhibitors of amyloid formation by amyloid β peptides (Aβ; see picture: unlike the top POM (red), the bottom POM (dark green) inhibited amyloid formation). The inhibition selectivity of POMs is due to size-specific electrostatic interactions between POMs and Aβ through binding to the positively charged His13–Lys16 cluster region of Aβ. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.