炎症
先天免疫系统
巨噬细胞
免疫学
人口
细胞因子
组织修复
免疫系统
生物
医学
细胞生物学
体外
遗传学
环境卫生
标识
DOI:10.3410/f.10856957.14205058
摘要
A defining feature of inflammation is the accumulation of innate immune cells in the tissue that are thought to be recruited from the blood. We reveal that a distinct process exists in which tissue macrophages undergo rapid in situ proliferation in order to increase population density. This inflammatory mechanism occurred during T helper 2 (T(H)2)-related pathologies under the control of the archetypal T(H)2 cytokine interleukin-4 (IL-4) and was a fundamental component of T(H)2 inflammation because exogenous IL-4 was sufficient to drive accumulation of tissue macrophages through self-renewal. Thus, expansion of innate cells necessary for pathogen control or wound repair can occur without recruitment of potentially tissue-destructive inflammatory cells. PMID: 21566158 Funding information This work was supported by: Wellcome Trust, United Kingdom Medical Research Council, United Kingdom Grant ID: G0701437 NIAID NIH HHS, United States Grant ID: R01 AI070300 Medical Research Council, United Kingdom Grant ID: G0600818
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