Recent Developments in Transannular Reactions

Abstract Transannular reactions have shown a remarkable performance for the construction of polycyclic scaffolds from medium- or large-sized cyclic molecules in an unconventional manner. Recent examples of transannular reactions reported from 2011 have been reviewed, emphasizing the excellent performance of this approach when accessing the target compounds. This review also highlights how this methodology provides an alternative approach to other commonly used strategies for the construction of cyclic entities such as cyclization or cycloaddition reactions. 1 Introduction 2 Transannular Cycloadditions and Electrocyclizations 3 Transannular Conjugate Additions 4 Transannular 1,2-Addition to Ketones, Imines, Esters, and Amides 5 Transannular Reactions via Electrophilic Activation of Olefins 6 Transannular Ring-Opening of Epoxides 7 Transannular Alkylations of Enolates and Related Species 8 Miscellaneous Transannular Reactions 9 Concluding Remarks