A New Standard Immunosuppression Regimen in Severe Aplastic Anemia

Organ failure is a major cause of illness and death across medical conditions. In particular, primary failure of the bone marrow can result in various cytopenias. Aplastic anemia is the prototype of the bone marrow failure syndromes that are characterized by hypocellular marrow and pancytopenia, and severe aplastic anemia is fatal if untreated.1 Since the 1980s, clinical and experimental data have indicated an autoimmune cause in the majority of idiopathic cases of aplastic anemia.1 In a minority of cases, genetic defects that are associated with inherited forms of aplastic anemia usually manifest with characteristic physical signs in childhood.2 In immune . . .