Copper/Iron‐Cocatalyzed Cascade Perfluoroalkylation/Cyclization of 1,6‐Enynes with Iodoperfluoroalkanes

Abstract A copper/iron‐cocatalyzed fluoroalkylative cyclization of 1,6‐enynes with readily available iodoperfluoroalkanes reagents for the synthesis of the corresponding fluoroalkylated pyrrolidines and benzofuran derivatives is reported. This novel protocol provides a mild method for the construction of C sp 3 ‐CF 2 and exocyclic double bonds in one step with high regio‐ and stereo‐selectivities. magnified image