(20S) Ginsenoside Rh2 Inhibits STAT3/VEGF Signaling by Targeting Annexin A2

车站3 膜联蛋白A2 膜联蛋白 STAT蛋白 磷酸化 细胞生物学 生物 血管生成 分子生物学 酪氨酸磷酸化 癌症研究 化学 流式细胞术
作者
Yushi Wang,Chen Chen,Shiyin Zhang,Yang Li,Yinghua Jin
出处
期刊:International Journal of Molecular Sciences [MDPI AG]
卷期号:22 (17): 9289-9289 被引量:10
标识
DOI:10.3390/ijms22179289
摘要

Signal transducers and activators of transcription 3 (STAT3) acts as a transcriptional signal transducer, converting cytokine stimulation into specific gene expression. In tumor cells, aberrant activation of the tyrosine kinase pathway leads to excessive and continuous activation of STAT3, which provides further signals for tumor cell growth and surrounding angiogenesis. In this process, the tumor-associated protein Annexin A2 interacts with STAT3 and promotes Tyr705 phosphorylation and STAT3 transcriptional activation. In this study, we found that (20S) ginsenoside Rh2 (G-Rh2), a natural compound inhibitor of Annexin A2, inhibited STAT3 activity in HepG2 cells. (20S) G-Rh2 interfered with the interaction between Annexin A2 and STAT3, and inhibited Tyr705 phosphorylation and subsequent transcriptional activity. The inhibitory activity of STAT3 leaded to the negative regulation of the four VEGFs, which significantly reduced the enhanced growth and migration ability of HUVECs in co-culture system. In addition, (20S)G-Rh2 failed to inhibit STAT3 activity in cells overexpressing (20S)G-Rh2 binding-deficient Annexin A2-K301A mutant, further proving Annexin A2-mediated inhibition of STAT3 by (20S)G-Rh2. These results indicate that (20S)G-Rh2 is a potent inhibitor of STAT3, predicting the potential activity of (20S)G-Rh2 in targeted therapy applications.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
深情安青应助平常的硬币采纳,获得10
1秒前
1秒前
大个应助聪明的小海豚采纳,获得10
2秒前
Ma完成签到,获得积分10
2秒前
飞飞飞完成签到,获得积分10
2秒前
winsgao发布了新的文献求助10
4秒前
南宫誉完成签到,获得积分10
4秒前
舟舟完成签到 ,获得积分10
5秒前
崽崽完成签到,获得积分10
5秒前
xiaomt0518发布了新的文献求助10
6秒前
7秒前
善学以致用应助风和日丽采纳,获得30
8秒前
冰墨发布了新的文献求助10
10秒前
所所应助xiao采纳,获得10
10秒前
_呱_应助动人的百褶裙采纳,获得10
10秒前
慕青应助冷艳中蓝采纳,获得10
11秒前
11秒前
Hello应助科研通管家采纳,获得10
12秒前
JamesPei应助科研通管家采纳,获得10
12秒前
12秒前
领导范儿应助科研通管家采纳,获得10
12秒前
星辰大海应助jinxingyue采纳,获得10
12秒前
jwj发布了新的文献求助10
12秒前
李爱国应助科研通管家采纳,获得30
12秒前
12秒前
丘比特应助科研通管家采纳,获得10
12秒前
星辰大海应助科研通管家采纳,获得10
12秒前
香蕉觅云应助科研通管家采纳,获得10
13秒前
情怀应助科研通管家采纳,获得10
13秒前
大大蕾发布了新的文献求助10
13秒前
13秒前
852应助科研通管家采纳,获得30
13秒前
ding应助科研通管家采纳,获得10
13秒前
13秒前
15秒前
15秒前
zz发布了新的文献求助10
15秒前
CodeCraft应助lcs采纳,获得10
16秒前
memory发布了新的文献求助10
16秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
How Maoism Was Made: Reconstructing China, 1949-1965 800
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 600
Promoting women's entrepreneurship in developing countries: the case of the world's largest women-owned community-based enterprise 500
Shining Light on the Dark Side of Personality 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3309599
求助须知:如何正确求助?哪些是违规求助? 2942884
关于积分的说明 8511456
捐赠科研通 2617981
什么是DOI,文献DOI怎么找? 1430741
科研通“疑难数据库(出版商)”最低求助积分说明 664212
邀请新用户注册赠送积分活动 649424