硫
阳离子聚合
聚合物
部分
抗菌活性
单体
组合化学
细菌
抗菌剂
材料科学
膜
化学
高分子化学
有机化学
抗生素
生物化学
生物
盐(化学)
遗传学
作者
Yongjin Hu,Jinghua Zhao,Jingyan Zhang,Zhiyuan Zhu,Jingyi Rao
出处
期刊:ACS Macro Letters
[American Chemical Society]
日期:2021-07-15
卷期号:10 (8): 990-995
被引量:24
标识
DOI:10.1021/acsmacrolett.1c00340
摘要
Incorporation of cationic groups into polymers represents one of the most widely used strategies to prepare antibacterial materials. Sulfonium, as a typical cationic moiety, displays potent antibacterial efficacy in the form of small molecules, however, has long underperformed in polymeric systems. Herein, we developed a series of alternating polysulfoniums, where the hydrophobicity of each alternating unit can be accurately tuned by altering the monomer precursors. Excellent antibacterial activity against a broad spectrum of clinically relevant bacteria, including Methicillin-resistant Staphylococcus aureus, can be obtained in the optimal compositions with minimum bactericidal concentrations in the range of 1.25-10 μg/mL, as well as negligible hemolytic effect at polymer concentrations even up to 10000 μg/mL. Bacteria do not readily develop resistance to polysulfoniums due to the antibacterial action is possibly the membrane disrupting mechanism. This work demonstrates sulfonium-based polymers with well-defined sequences can function as a promising candidate to combat drug-resistant bacterial infection.
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