已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Inflammatory subgroups of schizophrenia and their association with brain structure: A semi-supervised machine learning examination of heterogeneity

精神分裂症(面向对象编程) 神经认知 灰质 精神病 炎症 基于体素的形态计量学 医学 扣带回前部 心理学 内科学 精神科 认知 磁共振成像 白质 放射科
作者
Paris Alexandros Lalousis,Lianne Schmaal,Stephen J. Wood,Renate Reniers,Vanessa Cropley,Andrew Watson,Christos Pantelis,John Suckling,Nicholas M. Barnes,Carmine M. Pariante,Peter B. Jones,Eileen M. Joyce,Thomas R. E. Barnes,Stephen M. Lawrie,Nusrat Husain,Paola Dazzan,J.F.W. Deakin,Cynthia Shannon Weickert,Rachel Upthegrove
出处
期刊:Brain Behavior and Immunity [Elsevier BV]
卷期号:113: 166-175 被引量:19
标识
DOI:10.1016/j.bbi.2023.06.023
摘要

Immune system dysfunction is hypothesised to contribute to structural brain changes through aberrant synaptic pruning in schizophrenia. However, evidence is mixed and there is a lack of evidence of inflammation and its effect on grey matter volume (GMV) in patients. We hypothesised that inflammatory subgroups can be identified and that the subgroups will show distinct neuroanatomical and neurocognitive profiles. The total sample consisted of 1067 participants (chronic patients with schizophrenia n = 467 and healthy controls (HCs) n = 600) from the Australia Schizophrenia Research Bank (ASRB) dataset, together with 218 recent-onset patients with schizophrenia from the external Benefit of Minocycline on Negative Symptoms of Psychosis: Extent and Mechanism (BeneMin) dataset. HYDRA (HeterogeneitY through DiscRiminant Analysis) was used to separate schizophrenia from HC and define disease-related subgroups based on inflammatory markers. Voxel-based morphometry and inferential statistics were used to explore GMV alterations and neurocognitive deficits in these subgroups. An optimal clustering solution revealed five main schizophrenia groups separable from HC: Low Inflammation, Elevated CRP, Elevated IL-6/IL-8, Elevated IFN-γ, and Elevated IL-10 with an adjusted Rand index of 0.573. When compared with the healthy controls, the IL-6/IL-8 cluster showed the most widespread, including the anterior cingulate, GMV reduction. The IFN-γ inflammation cluster showed the least GMV reduction and impairment of cognitive performance. The CRP and the Low Inflammation clusters dominated in the younger external dataset. Inflammation in schizophrenia may not be merely a case of low vs high, but rather there are pluripotent, heterogeneous mechanisms at play which could be reliably identified based on accessible, peripheral measures. This could inform the successful development of targeted interventions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
一直向前发布了新的文献求助10
2秒前
honeylaker发布了新的文献求助10
3秒前
bkagyin应助zsw采纳,获得10
3秒前
3秒前
4秒前
4秒前
斯文败类应助科研通管家采纳,获得10
4秒前
共享精神应助科研通管家采纳,获得10
4秒前
科研通AI2S应助科研通管家采纳,获得10
4秒前
Owen应助科研通管家采纳,获得10
4秒前
脑洞疼应助科研通管家采纳,获得10
5秒前
CipherSage应助科研通管家采纳,获得10
5秒前
我是老大应助科研通管家采纳,获得10
5秒前
1234发布了新的文献求助10
6秒前
乖猫要努力应助潘善若采纳,获得10
7秒前
41应助潘善若采纳,获得10
7秒前
乖猫要努力应助潘善若采纳,获得10
8秒前
yar应助潘善若采纳,获得10
8秒前
9秒前
涛1118发布了新的文献求助10
10秒前
陶瓷小罐完成签到 ,获得积分10
12秒前
15秒前
胡萝卜发布了新的文献求助10
15秒前
Lion发布了新的文献求助10
16秒前
16秒前
英俊的铭应助小羊采纳,获得10
17秒前
Tuesday完成签到 ,获得积分10
18秒前
VIAI发布了新的文献求助10
19秒前
Ha完成签到,获得积分10
21秒前
beyondjun完成签到,获得积分10
22秒前
深情安青应助温柔烧鹅采纳,获得10
22秒前
23秒前
cbxzhsun发布了新的文献求助10
23秒前
圈圈完成签到 ,获得积分10
24秒前
卖辣条的小浣熊完成签到,获得积分10
24秒前
25秒前
Yuki发布了新的文献求助10
28秒前
研友_VZG7GZ应助VIAI采纳,获得10
29秒前
SUE发布了新的文献求助10
30秒前
Kirito完成签到 ,获得积分0
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
Aktuelle Entwicklungen in der linguistischen Forschung 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989868
求助须知:如何正确求助?哪些是违规求助? 3531994
关于积分的说明 11255752
捐赠科研通 3270793
什么是DOI,文献DOI怎么找? 1805053
邀请新用户注册赠送积分活动 882215
科研通“疑难数据库(出版商)”最低求助积分说明 809208