Bronchodilator reversibility in patients with asthma and persistent airflow limitation

We read with interest the Article in The Lancet Respiratory Medicine by Tessa M Kole and colleagues1 about predictors of persistent airflow limitation (PAL) in patients with asthma. In this post-hoc analysis of the ATLANTIS study, this phenotype of asthma was more commonly seem in individuals who developed the condition at older ages, who had longer duration of the disease, male sex, higher blood eosinophil counts, increased small airway dysfunction, and more exacerbations during 1 year of follow-up.