串扰
信号转导
Wnt信号通路
骨吸收
骨重建
医学
骨质疏松症
生物
生物信息学
细胞生物学
神经科学
病理
内科学
物理
光学
作者
Morteza Nakhaei Amroodi,Mazaher Maghsoudloo,Shayan Amiri,Khatere Mokhtari,Parnaz Mohseni,Azadeh Pourmarjani,Behdokht Jamali,Elaheh Mohandesi Khosroshahi,Saba Asadi,Pouria Tabrizian,Maliheh Entezari,Mehrdad Hashemi,Runlan Wan
标识
DOI:10.1016/j.biopha.2024.116954
摘要
Osteoporosis, characterized by compromised bone density and microarchitecture, represents a significant global health challenge, particularly in aging populations. This comprehensive review delves into the intricate signaling pathways implicated in the pathogenesis of osteoporosis, providing valuable insights into the pivotal role of signal transduction in maintaining bone homeostasis. The exploration encompasses cellular signaling pathways such as Wnt, Notch, JAK/STAT, NF-κB, and TGF-β, all of which play crucial roles in bone remodeling. The dysregulation of these pathways is a contributing factor to osteoporosis, necessitating a profound understanding of their complexities to unveil the molecular mechanisms underlying bone loss. The review highlights the pathological significance of disrupted signaling in osteoporosis, emphasizing how these deviations impact the functionality of osteoblasts and osteoclasts, ultimately resulting in heightened bone resorption and compromised bone formation. A nuanced analysis of the intricate crosstalk between these pathways is provided to underscore their relevance in the pathophysiology of osteoporosis. Furthermore, the study addresses some of the most crucial long non-coding RNAs (lncRNAs) associated with osteoporosis, adding an additional layer of academic depth to the exploration of immune system involvement in various types of osteoporosis. Finally, we propose that SKP1 can serve as a potential biomarker in osteoporosis.
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