代谢组学
肺癌
免疫系统
多路复用
不利影响
流式细胞术
医学
生物标志物
生物信息学
肿瘤科
内科学
生物
免疫学
化学
生物化学
作者
Jiayi Gao,Ping Zhang,Xin Nie,Min Tang,Yue Yuan,Liuer He,Xue Wang,Junling Ma,Lin Li
出处
期刊:iScience
[Elsevier]
日期:2024-05-08
卷期号:27 (6): 109946-109946
被引量:3
标识
DOI:10.1016/j.isci.2024.109946
摘要
The clinical success of immune checkpoint inhibitors is compromised by the fact of immune-related adverse events (irAEs), especially for older patients. To identify predictive biomarkers for older patients with irAEs, we used multiplex immunoassay and flow cytometry and liquid chromatography-tandem mass spectrometry to test immune factors and plasma protein and metabolites levels in non-small cell lung cancer (NSCLC) patients. The results showed that older patients with irAEs displayed lower CD28, CD4
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