Linoleic acid induces red blood cells and hemoglobin damage via oxidative mechanism.

亚油酸 血红蛋白 红细胞 化学 氧化应激 超氧化物歧化酶 谷胱甘肽过氧化物酶 生物化学 体内 全血 内科学 内分泌学 医学 脂肪酸 生物 生物技术
作者
Tao Yuan,Wenbin Fan,Yu Cong,Haidong Xu,Chengjun Li,Jia Meng,Nirong Bao,Jianning Zhao
出处
期刊:PubMed 卷期号:8 (5): 5044-52 被引量:33
链接
标识
摘要

Hidden blood loss typically occurs following total hip arthroplasty (THA) and total knee arthroplasty (TKA) and is thought to be related to free fatty acid (FFA). To study the effect of linoleic acid on red blood cells and to examine the pathogenesis of hidden blood loss in vivo, we generated an animal model by injecting linoleic acid into the tail veins of rats. We collected blood samples and determined red blood cell count (RBC) and levels of hemoglobin (Hb), as well as the oxidation and reducing agents in the blood, including glutathione peroxidase (GSH-PX), total superoxide dismutase (T-SOD), hydrogen peroxide (H2O2), and ferryl hemoglobin (Fe4+=O2-), which is generated by the oxidation of Hb. Hidden blood loss occurred when linoleic acid was administered at a concentration of 60 mmol/L; RBC and Hb levels were significantly reduced by 24 h post-injection. This was followed by erythrocyte deformation, reduced activity of GSH-PX and T-SOD, and decreased levels of H2O2. This was accompanied by an increase in ferryl species, which likely contributes to oxidative stress in vivo. Our findings suggest that linoleic acid enhances acute red blood cell injury. Hb and RBC began to increase by 72 h, potentially resulting from linoleic acid metabolism. Thus, elevated levels of linoleic acid in the blood cause acute oxidative damage to red blood cells, eventually leading to partial acute anemia. These findings highlight the pathophysiology underlying hidden blood loss.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
简墨完成签到,获得积分10
刚刚
CipherSage应助博修采纳,获得10
刚刚
刚刚
顺心醉蝶完成签到 ,获得积分10
2秒前
3秒前
乐乐应助白桃采纳,获得10
3秒前
3秒前
共享精神应助端庄的石头采纳,获得10
4秒前
6小瓶子发布了新的文献求助10
4秒前
香蕉觅云应助YN采纳,获得10
5秒前
源儿发布了新的文献求助10
6秒前
GAO发布了新的文献求助10
7秒前
weilong发布了新的文献求助10
8秒前
感动的红酒应助沉默似狮采纳,获得20
9秒前
咔什么嚓完成签到,获得积分10
13秒前
零九二一关注了科研通微信公众号
13秒前
mz完成签到 ,获得积分10
14秒前
15秒前
小橘子发布了新的文献求助10
15秒前
大模型应助冰雪物语采纳,获得10
16秒前
情怀应助昵昵昵昵呀采纳,获得10
18秒前
白桃发布了新的文献求助10
19秒前
lonely完成签到,获得积分10
20秒前
20秒前
20秒前
华仔应助付品聪采纳,获得10
21秒前
23秒前
24秒前
24秒前
25秒前
咕噜咕噜噜熊完成签到,获得积分10
26秒前
美好斓发布了新的文献求助30
26秒前
量子星尘发布了新的文献求助30
26秒前
26秒前
26秒前
南至发布了新的文献求助10
27秒前
28秒前
28秒前
iwaking发布了新的文献求助10
28秒前
深情安青应助hu采纳,获得10
28秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 1000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 310
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3979704
求助须知:如何正确求助?哪些是违规求助? 3523700
关于积分的说明 11218393
捐赠科研通 3261224
什么是DOI,文献DOI怎么找? 1800490
邀请新用户注册赠送积分活动 879113
科研通“疑难数据库(出版商)”最低求助积分说明 807182