介孔二氧化硅
榄香烯
丙烯酸
纳米颗粒
化学
药物输送
生物利用度
化学工程
纳米技术
色谱法
材料科学
共聚物
介孔材料
聚合物
有机化学
药理学
生物化学
工程类
催化作用
细胞凋亡
医学
作者
Beibei Yan,Yancai Wang,Yingying Ma,Juan Zhao,Yangyang Liu,Lulu Wang
标识
DOI:10.1016/j.ijpharm.2019.118768
摘要
The strategy of formulating poorly soluble actives as liquid self-micro emulsifying drug delivery system (SMEDDS) has been explored in more than a thousand research papers. However, there have been a limited number of reports on pH sensitive solid SMEDDS. This study explored the feasibility of using poly (acrylic acid) modified mesoporous silica nanoparticles (MSNs-PAA) as a pH-mediated solid SMEDDS carrier for β-elemene. This SMEDDS was optimized using a central composite design-response surface methodology, pseudo ternary phase diagrams, and studies of the preliminary stability. MSNs-PAA was synthesized and used for loading β-elemene SMEDDS. Ele/MSNs-PAA was capable of pH-sensitive release of β-elemene. In addition to structural analyses, the morphological and stability of this SMEDDS was also investigated. In comparison of the β-elemene solution and the SMEDDS, the Ele/MSNs-PAA demonstrated improved Cmax, AUC and MRT after oral administration. These results suggested that the MSNs-PAA could be further developed as a promising approach for the pH sensitive release of β-elemene SMEDDS with enhanced oral bioavailability.
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