医学
肌萎缩
肌萎缩性肥胖
倾向得分匹配
混淆
肥胖
优势比
内科学
外科
作者
Syed Khalid,Elie Massaad,Ali Kiapour,Christopher P. Bridge,Grant H. Rigney,Alison Burrows,Jane Shim,Rafael De la Garza Ramos,Daniel G. Tobert,Andrew J. Schoenfeld,Theresa Williamson,Ganesh M. Shankar,John H. Shin
出处
期刊:Journal of neurosurgery
[Journal of Neurosurgery Publishing Group]
日期:2023-12-01
卷期号:: 1-10
被引量:3
标识
DOI:10.3171/2023.9.spine23864
摘要
OBJECTIVE The distributions and proportions of lean and fat tissues may help better assess the prognosis and outcomes of patients with spinal metastases. Specifically, in obese patients, sarcopenia may be easily overlooked as a poor prognostic indicator. The role of this body phenotype, sarcopenic obesity (SO), has not been adequately studied among patients undergoing surgical treatment for spinal metastases. To this end, here the authors investigated the role of SO as a potential prognostic factor in patients undergoing surgical treatment for spinal metastases. METHODS The authors identified patients who underwent surgical treatment for spinal metastases between 2010 and 2020. A validated deep learning approach evaluated sarcopenia and adiposity on routine preoperative CT images. Based on composition analyses, patients were classified with SO or nonsarcopenic obesity. After nearest-neighbor propensity matching that accounted for confounders, the authors compared the rates and odds of postoperative complications, length of stay, 30-day readmission, and all-cause mortality at 90 days and 1 year between the SO and nonsarcopenic obesity groups. RESULTS A total of 62 patients with obesity underwent surgical treatment for spinal metastases during the study period. Of these, 37 patients had nonsarcopenic obesity and 25 had SO. After propensity matching, 50 records were evaluated that were equally composed of patients with nonsarcopenic obesity and SO (25 patients each). Patients with SO were noted to have increased odds of nonhome discharge (OR 6.0, 95% CI 1.69–21.26), 30-day readmission (OR 3.27, 95% CI 1.01–10.62), and 90-day (OR 4.85, 95% CI 1.29–18.26) and 1-year (OR 3.78, 95% CI 1.17–12.19) mortality, as well as increased time to mortality after surgery (12.60 ± 19.84 months vs 37.16 ± 35.19 months, p = 0.002; standardized mean difference 0.86). No significant differences were noted in terms of length of stay or postoperative complications when comparing the two groups (p > 0.05). CONCLUSIONS The SO phenotype was associated with increased odds of nonhome discharge, readmission, and postoperative mortality. This study suggests that SO may be an important prognostic factor to consider when developing care plans for patients with spinal metastases.
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