Solid‐Acid Catalyzed Continuous‐Flow Aminolysis of Epoxides

We report a solid‐acid catalyzed aminolysis of epoxides under continuous‐flow conditions. A titania‐zirconia supported molybdenum oxide catalyst demonstrated exceptional substrate compatibility, enabling the synthesis of β‐amino alcohols in excellent yields with high catalyst durability. Characterization of the catalyst revealed the crucial role of the titania‐zirconia ratio in optimizing its performance. Furthermore, this method was applied to the efficient, sequential‐flow synthesis of a rivaroxaban intermediate (an oral anticoagulant and the first direct factor Xa inhibitor), combining a hydrogenation step with the aminolysis reaction without the need for intermediate isolation.