中性粒细胞胞外陷阱
骨肉瘤
肿瘤微环境
免疫抑制
免疫学
癌症研究
医学
发病机制
免疫系统
炎症
作者
Ming Xia,Yu Han,Lihui Sun,Dongbo Li,Changlian Zhu,Dongsong Li
标识
DOI:10.3389/fimmu.2024.1490712
摘要
Osteosarcoma, a highly aggressive malignant bone tumor, is significantly influenced by the intricate interactions within its tumor microenvironment (TME), particularly involving neutrophils. This review delineates the multifaceted roles of neutrophils, including tumor-associated neutrophils (TANs) and neutrophil extracellular traps (NETs), in osteosarcoma’s pathogenesis. TANs exhibit both pro- and anti-tumor phenotypes, modulating tumor growth and immune evasion, while NETs facilitate tumor cell adhesion, migration, and immunosuppression. Clinically, neutrophil-related markers such as the neutrophil-to-lymphocyte ratio (NLR) predict patient outcomes, highlighting the potential for neutrophil-targeted therapies. Unraveling these complex interactions is crucial for developing novel treatment strategies that harness the TME to improve osteosarcoma management.
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