脚手架
材料科学
生物医学工程
再生(生物学)
组织工程
药物输送
骨组织
骨愈合
骨结构
纳米技术
医学
外科
细胞生物学
生物
作者
Zhen Cheng,Yanbin Shi,Wenguang Wang,Guangzhen Zhou,Heng Li,Guimei Lin,Fei Wang,Bingtao Tang,Xuelin Li
出处
期刊:Biofabrication
[IOP Publishing]
日期:2024-04-30
被引量:1
标识
DOI:10.1088/1758-5090/ad4595
摘要
Abstract Bone scaffolds are widely employed for treating various bone disorders, including defects, fractures, and accidents. Gradient bone scaffolds present a promising approach by incorporating gradients in shape, porosity, density, and other properties, mimicking the natural human body structure. This design offers several advantages over traditional scaffolds. A key advantage is the enhanced matching of human tissue properties, facilitating cell adhesion and migration. Furthermore, the gradient structure fosters a smooth transition between scaffold and surrounding tissue, minimizing the risk of inflammation or rejection. Mechanical stability is also improved, providing better support for bone regeneration. Additionally, gradient bone scaffolds can integrate drug delivery systems, enabling controlled release of drugs or growth factors to promote specific cellular activities during the healing process. This comprehensive review examines the design aspects of gradient bone scaffolds, encompassing structure and drug delivery capabilities. By optimizing the scaffold's inherent advantages through gradient design, bone regeneration outcomes can be improved. The insights presented in this article contribute to the academic understanding of gradient bone scaffolds and their applications in bone tissue engineering.
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