T细胞受体
抗原
细胞生物学
T细胞
生物
受体
细胞
计算生物学
生物物理学
化学
免疫学
生物化学
免疫系统
作者
Adam M Rochussen,Anna Lippert,Gillian M. Griffiths
标识
DOI:10.1016/j.coi.2023.102309
摘要
T cells recognize pathogenic antigens via the T-cell antigen receptor (TCR). This protein complex binds to antigen fragments on the surface of antigen-presenting cells. To understand how cellular activation can ensue rapidly from molecular recognition, the localization and distribution of the TCR on the surface of the resting T cell are of particular importance. Conflicting results regarding TCR distribution have emerged from recent studies using a range of imaging techniques, including total internal reflection and single-molecule localization microscopy modalities. Here, we review the differing results and the potential biases inherent in differing imaging approaches. In addition, we review studies showing the impact of differing imaging surfaces on T-cell activation.
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