Nickel‐Catalyzed Reductive Cross‐Coupling of (Hetero)aryl Halides with 2‐Chloro‐1,1‐difluoroethane: Facile Access to 2,2‐Difluoroethylated Aromatics

Abstract A mild and efficient nickel‐catalyzed 2,2‐difluoroethylation of (hetero)aryl halides with readily available 2‐chloro‐1,1‐difluoroethane has been developed. The reductive cross‐coupling reaction is synthetically simple and exhibits good functional group tolerance. This approach provides a facile access to synthesize 2,2‐difluoroethylated molecules for drug discovery.