查尔酮
外周血单个核细胞
细胞因子
流式细胞术
细胞生长
细胞内
化学
药理学
罗勒
生物化学
生物
分子生物学
免疫学
体外
立体化学
植物
作者
Lea Barfod,K. Kemp,Majbritt Hansen,A Kharazmi
标识
DOI:10.1016/s1567-5769(01)00202-8
摘要
Licochalcone A (LicA), an oxygenated chalcone, has been shown to inhibit the growth of both parasites and bacteria. In this study, we investigated the effect of LicA and four synthetic analogues on the activity of human peripheral blood mononuclear cell proliferation and cytokine production. Four out of five chalcones tested inhibited the proliferation of lymphocytes measured by thymidine incorporation and by flow cytometry. The production of pro- and anti-inflammatory cytokines from monocytes and T cells was also inhibited by four of five chalcones. Furthermore, intracellular detection of cytokines revealed that the chalcones inhibited the production rather than the release of the cytokines. Taken together, these results indicate that LicA and some analogues may have immunomodulatory effects, and may thus be candidates not only as anti-microbial agents, but also for the treatment of other types of diseases.
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