医学
红斑狼疮
系统性红斑狼疮
狼疮性肾炎
颧骨皮疹
自身抗体
抗核抗体
抗体
免疫学
内科学
自身免疫性疾病
羟基氯喹
作者
Maraina Ch,Kamaliah,Ishak M
出处
期刊:Asian Pacific Journal of Allergy and Immunology
[Allergy, Asthma, and Immunology Association of Thailand]
日期:2002-12-01
卷期号:20 (4): 279-282
被引量:3
摘要
Anti-nuclear antibody (ANA) negative systemic lupus erythematosus (SLE) occurs in about 4-13% of SLE cases. A small group of ANA negative SLE patients with positive anti-Ro antibodies usually present with typical vasculitic skin lesions which can be associated with photosensitivity, renal disease, congenital heart block or neonatal lupus. We present a case of a persistently ANA negative patient who presented with joint pain, rashes, mouth ulcer and alopecia. Clinical diagnosis of systemic lupus erythematosus was made even though ANA was negative. She was started on steroids and went into remission. Later, she developed several episodes of convulsions associated with fever and prominent vasculitic lesions. The patient was also found to have microscopic hematuria, proteinuria, anemia and thrombocytopenia. Renal biopsy showed lupus nephritis class 1B. Due to the prominent skin lesions, we performed anti-extractable nuclear antigens (ENA) antibodies test and anti-Ro turned out to be positive. The final diagnosis was ANA negative SLE (Ro lupus) with cutaneous, renal, musculoskeletal, hematological and cerebral Involvement.
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