热带假丝酵母
克鲁斯假丝酵母
白色念珠菌
两性霉素B
弥漫性血管内凝血
生物
微生物学
血培养
急性白血病
免疫学
医学
白血病
内科学
抗真菌
抗生素
作者
Sandin Rl,Meier Cs,Crowder Ml,Greene Jn
出处
期刊:PubMed
日期:1993-05-01
卷期号:117 (5): 521-3
被引量:5
摘要
Reports of the concurrent isolation of more than one non-albicans species of Candida from blood cultures of immunocompromised patients with disseminated candidiasis are extremely infrequent. We report on the isolation of Candida krusei and Candida tropicalis from 17 blood cultures that were taken from a 67-year-old white man with a diagnosis of acute biphenotypic leukemia during a 2-week period of hospitalization for induction chemotherapy. Despite receiving high-dose amphotericin B throughout this period, the status of the patient worsened, and he experienced pancytopenia, hypernatremia, azotemia, and disseminated intravascular coagulation, which led to his death. Candida krusei and C tropicalis were isolated concurrently from 10 of the 17 blood cultures, while C krusei was the single isolate in three cultures and C tropicalis was isolated alone in four cultures. Each species manifested markedly different colonial morphological features. This case report serves to emphasize to microbiologists that they must exercise extreme suspicion when non-albicans species of Candida are isolated singly or concurrently from blood cultures in neutropenic patients, given the increasing clinical significance of these yeasts.
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