有效载荷(计算)
抗体-药物偶联物
药品
连接器
计算生物学
计算机科学
化学
药理学
癌症研究
医学
纳米技术
单克隆抗体
抗体
生物
免疫学
材料科学
操作系统
网络数据包
计算机网络
作者
Vesela Kostova,Patrice Désos,Jérôme-Benoît Starck,András Kotschy
摘要
Combining the selective targeting of tumor cells through antigen-directed recognition and potent cell-killing by cytotoxic payloads, antibody-drug conjugates (ADCs) have emerged in recent years as an efficient therapeutic approach for the treatment of various cancers. Besides a number of approved drugs already on the market, there is a formidable follow-up of ADC candidates in clinical development. While selection of the appropriate antibody (A) and drug payload (D) is dictated by the pharmacology of the targeted disease, one has a broader choice of the conjugating linker (C). In the present paper, we review the chemistry of ADCs with a particular emphasis on the medicinal chemistry perspective, focusing on the chemical methods that enable the efficient assembly of the ADC from its three components and the controlled release of the drug payload.
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