Gut Microbiota Changes and Their Correlation with Cognitive and Neuropsychiatric Symptoms in Alzheimer’s Disease

肠道菌群 发病机制 鞘脂单胞菌属 认知 肠-脑轴 医学 疾病 生物 粪便 双歧杆菌 乳酸菌 痴呆 认知功能衰退 失调 阿尔茨海默病 心理学 临床心理学 微生物群 微生物学 内科学 免疫学 细菌 16S核糖体RNA 遗传学
作者
Yunzhe Zhou,Yan Wang,Meina Quan,Huiying Zhao,Jianping Jia
出处
期刊:Journal of Alzheimer's Disease [IOS Press]
卷期号:81 (2): 583-595 被引量:19
标识
DOI:10.3233/jad-201497
摘要

Background: Gut microbiota can influence human brain function and behavior. Recent studies showed that gut microbiota might play an important role in the pathogenesis of Alzheimer’s disease (AD). Objective: To investigate the composition of gut microbiota in AD patients and their association with cognitive function and neuropsychiatric symptoms (NPS). Methods: The fecal samples from 60 AD patients (30 with NPS and 30 without NPS) and 32 healthy control subjects (HC) were collected and analyzed by 16S ribosomal RNA sequencing. The functional variations of gut microbiota were predicted using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States. The correlation between different bacterial taxa and cognitive (Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR)), and NPS measures were analyzed. Results: The fecal microbial composition of AD patients was quite distinct from HC. Bifidobacterium, Sphingomonas, Lactobacillus, and Blautia were enriched, while Odoribacter, Anaerobacterium, and Papillibacter were reduced. AD patients with NPS showed decreased Chitinophagaceae, Taibaiella, and Anaerobacterium compared with those without NPS. Functional pathways were different between AD and HC, and between AD patients with and without NPS. Correlation analysis showed that Sphingomonas correlated negatively with MMSE; Anaerobacterium and Papillibacter correlated positively with MMSE and negatively with CDR. Cytophagia, Rhodospirillaceae, and Cellvibrio correlated positively with NPS, while Chitinophagaceae, Taibaiella, and Anaerobacterium correlated negatively with NPS. Conclusion: AD patients have gut microbiota alterations related to cognition, and differential taxa between AD patients with and without NPS associated differently with NPS domains, which helps further understand the pathogenesis of AD and explore potential therapeutic targets.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
香蕉子骞发布了新的文献求助10
1秒前
2秒前
ccc完成签到,获得积分10
2秒前
从心应助yipyip采纳,获得10
3秒前
5秒前
5秒前
三叶草完成签到,获得积分10
6秒前
6秒前
6秒前
7秒前
QQQ完成签到,获得积分10
8秒前
8秒前
8秒前
Xie发布了新的文献求助10
9秒前
myheng完成签到 ,获得积分10
9秒前
Orange应助九九采纳,获得10
9秒前
爱笑夜蕾发布了新的文献求助10
9秒前
归尘发布了新的文献求助10
9秒前
午后两点最热完成签到,获得积分10
11秒前
小蘑菇应助GJH采纳,获得10
12秒前
12秒前
科研通AI5应助hnxxangel采纳,获得10
12秒前
小二郎应助kuer采纳,获得10
13秒前
唐太君发布了新的文献求助10
13秒前
15秒前
完美世界应助疯狂的师采纳,获得10
15秒前
15秒前
微笑的小蚂蚁完成签到,获得积分10
18秒前
mof发布了新的文献求助10
19秒前
hgc发布了新的文献求助10
20秒前
大模型应助笑点低的鸿采纳,获得10
21秒前
22秒前
23秒前
24秒前
26秒前
26秒前
27秒前
Stronger发布了新的文献求助10
28秒前
ASDS发布了新的文献求助10
28秒前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3542931
求助须知:如何正确求助?哪些是违规求助? 3120348
关于积分的说明 9342270
捐赠科研通 2818338
什么是DOI,文献DOI怎么找? 1549524
邀请新用户注册赠送积分活动 722168
科研通“疑难数据库(出版商)”最低求助积分说明 712992