屈螺酮
地塞米松
药丸
血管舒张
医学
炔雌醇
生理学
内科学
药理学
妇科
人口
研究方法
计划生育
环境卫生
作者
Abby K. Thompson,A. Przemska,D. Vasilopoulou,K. J. Newens,Christine M. Williams
标识
DOI:10.1111/j.1549-8719.2011.00094.x
摘要
Please cite this paper as: Thompson, Przemska, Vasilopoulou, Newens, and Williams (2011). Combined Oral Contraceptive Pills Containing Desogestrel or Drospirenone Enhance Large Vessel and Microvasculature Vasodilation in Healthy Premenopausal Women. Microcirculation 18(5), 339–346. Abstract Objective: To determine the effects of different COCs on endothelial function. Background: COCs all contain ethinylestradiol, but different progestins; three of the more common progestins are DSG, LN, and DR. Ethinylestradiol enhances some measures of vascular reactivity, but certain progestins may increase risk of vascular diseases and impair endothelial vasodilation. Methods: Twenty-nine healthy women taking COCs containing 30 μg ethinylestradiol and 150 μg DSG (Marvelon, n = 10), 150 μg LN (Microgynon, n = 10), or 3 mg DR (Yasmin, n = 9) had their vascular reactivity measured using various techniques during their pill-free week (days 5–7) and the third week of active pills (days 26–28). A reference group (n = 10) underwent the same measurements on two consecutive cycles. Results: FMD and LDI were significantly higher during active-pill visits than pill-free visits in women taking DSG and DR (p < 0.02), but not in women taking LN. There were no differences between the duplicate measures in the reference group. Conclusions: COCs containing 150 μg DSG or 3 mg DR significantly increase endothelium-dependent vasodilation in both large vessels and peripheral microvasculature. These effects may be due to the progestins exhibiting differential effects on eNOS expression.
科研通智能强力驱动
Strongly Powered by AbleSci AI