1 Pulmonary, Allergy & Critical Care Division, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 2 Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 3 School of Pharmacy, Northeastern University, Boston, MA 4 Department of Pharmacy and Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA *See also p. 335. The authors have disclosed that they do not have any potential conflicts of interest.