轨道轨道
色谱法
精液
化学
化学成分
化学成分
质谱法
标准物质
高效液相色谱法
生物
检出限
遗传学
有机化学
作者
Lu Wang,De-Yong Zhou,Lijuan Jiang,Jinhua Zhang,Wei Zhang,Yan-Yan Jiang,Bin Liu
出处
期刊:PubMed
日期:2019-05-01
卷期号:44 (10): 2102-2109
标识
DOI:10.19540/j.cnki.cjcmm.20190222.008
摘要
The main chemical constituents of naphthopyrone reference extract( NRE) with definite content and relatively fixed chemical composition were analyzed and determined. Ultra-high performance liquid chromatography-LTQ-Orbitrap XL mass spectrometry and high performance liquid chromatography were used to systematically study NRE from the aspects of main chemical components and determination. The results showed that the chemical composition of naphthopyrone reference extract of Cassiae Semen was relatively fixed,and seven naphthalopyranones were identified. Cassiaside B_2,cassiaside C_2,rubrofusarin-6-O-β-D-gentiobioside and cassiaside C were the main chemical constituents of NRE,of which the determination and uncertainty results were( 11. 40+ 0. 26) %,( 11. 68+0. 24) %,( 16. 60+0. 22) %,( 28. 8+0. 48) %,respectively. This study contributed to the accurate evaluation of NRE and the foundation for the application of NRE in the quality control of Cassiae Semen,and provided a new idea for the replacement of single chemical reference substance by the reference extract of traditional Chinese medicine.
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