Progress in myopia animal models

Myopia progressively damages ocular fundus morphology and visual function.Its mechanisms is a research hotspot in Ophthalmology.The establishment of an animal model for the study of myopia provides a good experimental platform,which is not limited by ethical and experimental means.Various animal models,have been developed such as domestic chickens,mice,tree shrew,guinea pigs,rabbits or marmosets.The effect of hyperopic and myopic defocus to animal eyes,the two-ways regulation effect on visual development,the influence of circadian rhythm,the different spectral eye axis growth and the axial growth related cytokines are currently investigated. Key words: myopia; animal model; form deprivation; defocus-induced