RNA聚合酶Ⅱ
RNA聚合酶Ⅱ全酶
抄写(语言学)
蛋白磷酸酶2
转录因子ⅡD
RNA聚合酶
细胞生物学
磷酸化
核糖核酸
分子生物学
聚合酶
生物
生物化学
磷酸酶
化学
酶
RNA依赖性RNA聚合酶
基因表达
基因
发起人
哲学
语言学
作者
Hai Zheng,Yilun Qi,Shibin Hu,Xuan Cao,Congling Xu,Zhenggang Yin,Xizi Chen,Yan Li,Weida Liu,Jie Li,Jiawei Wang,Gang Wei,Kaiwei Liang,Fei Chen,Yanhui Xu
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2020-11-27
卷期号:370 (6520)
被引量:131
标识
DOI:10.1126/science.abb5872
摘要
Dephosphorylating RNA polymerase II Transcription in metazoans requires coordination of multiple factors to control the progression of polymerases and the integrity of their RNA products. Zheng et al. identified a new dual-enzyme complex called INTAC, which is composed of protein phosphatase 2A (PP2A) core enzyme and the multisubunit RNA endonuclease Integrator. Structural and functional studies show that INTAC functions as a noncanonical PP2A holoenzyme that dephosphorylates the C-terminal domain of RNA polymerase II to attenuate transcription. This study provides a direct connection between PP2A-mediated dephosphorylation and transcriptional regulation, two fundamental cellular processes. Science , this issue p. eabb5872
科研通智能强力驱动
Strongly Powered by AbleSci AI