Pathway of Cell Death and Its Role in Virus Infection

上睑下垂 坏死性下垂 程序性细胞死亡 病毒 生物 免疫系统 先天免疫系统 病毒学 免疫学 细胞凋亡 埃博拉病毒 生物化学
作者
Xiaoxue Chen,Weiyan Zhang,Wei Yi,Liquan Yang,Xiaoyue Bi,Yanjie Lin,Wen Deng,Jianping Dong,Minghui Li,Yao Xie
出处
期刊:Viral Immunology [Mary Ann Liebert]
卷期号:35 (7): 444-456 被引量:5
标识
DOI:10.1089/vim.2022.0010
摘要

The global pandemic of SARS-CoV-2 in the past 2 years has aroused great attention to infectious diseases, and emerging virus outbreaks have brought huge challenges to the global health system. Viruses are specific pathogens that completely rely on host cells for their own survival and disease transmission. At present, a growing number of studies have proved that inducing the death of virus-infected cells can prevent the spread of virus and promote disease recovery. Therefore, many ways to induce the death of infected cells are considered to be beneficial to host immunity. Cell death is a basic biological phenomenon. Programmed cell death (PCD), as an important part of the host's innate immune response, provides effective protection against virus transmission. Pyroptosis, apoptosis, and necroptosis are the most commonly studied pathways of PCD. Recent studies have found that three pathways of cell death can be activated during virus infection. More and more studies have shown the existence of extensive connections between PCDs, and this complex relationship is defined as PANoptosis, an inflammatory PCD pathway regulated by the PANoptosome complex, whose characteristics cannot be explained by any of the three PCD pathways. During viral infection, PANoptosis can promote inflammatory response by inducing the production of inflammatory cytokines and cell death to exert an antiviral mechanism. This article reviews the various effects of cell death pathways during viral infection and provides new ideas for clinical antiviral therapy and related immunotherapy.
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