诱导多能干细胞
药物发现
疾病
药物开发
再生医学
神经科学
药品
计算生物学
生物
医学
生物信息学
细胞
药理学
胚胎干细胞
病理
遗传学
基因
作者
Martin W. Nicholson,Chien-Yu Ting,Darien Chan,Yu-Che Cheng,Yi-Chan Lee,Ching-Chuan Hsu,Ching-Ying Huang,Patrick C. Hsieh
出处
期刊:Cells
[MDPI AG]
日期:2022-06-06
卷期号:11 (11): 1853-1853
被引量:10
标识
DOI:10.3390/cells11111853
摘要
The advent of induced pluripotent stem cells (iPSCs) has advanced our understanding of the molecular mechanisms of human disease, drug discovery, and regenerative medicine. As such, the use of iPSCs in drug development and validation has shown a sharp increase in the past 15 years. Furthermore, many labs have been successful in reproducing many disease phenotypes, often difficult or impossible to capture, in commonly used cell lines or animal models. However, there still remain limitations such as the variability between iPSC lines as well as their maturity. Here, we aim to discuss the strategies in generating iPSC-derived cardiomyocytes and neurons for use in disease modeling, drug development and their use in cell therapy.
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