血管生成
软骨内骨化
机械敏感通道
压电1
细胞生物学
蛋白激酶B
骨愈合
膜内骨化
成骨细胞
医学
化学
生物
解剖
软骨
信号转导
内科学
离子通道
受体
体外
生物化学
作者
Peng Chen,Gangyu Zhang,Shan Jiang,Yile Ning,Bo Deng,Xianmei Pan,Silin Liu,Yu He,Lei Zhang,Rentao Wan,Zhiming Wu,Qi He,Jiang Yin,Haibin Wang,Jing Li
出处
期刊:Cell Calcium
[Elsevier]
日期:2021-07-01
卷期号:97: 102431-102431
被引量:40
标识
DOI:10.1016/j.ceca.2021.102431
摘要
Piezo1, a calcium-permeable non-selective cationic channel that senses mechanical stimulation in multicellular organisms, mediates various biological processes, including angiogenesis. The supply of nutrients and oxygen through newly formed blood vessels at the fractured lesion is critical for bone fracture repair. The elucidation of the underlying mechanisms involved in angiogenesis and bone repair can aid in improving fracture healing. Here, mice with endothelial cell-specific deletion of Piezo1 channels were used to examine the role of Piezo1 in the initiation of fracture healing. The expression and distribution of Piezo1 was explored in the vasculature of the bone. The deletion of endothelial Piezo1 resulted in impaired bone fracture repair, downregulation of calcium-activated proteolytic calpain activity during vascularization, inhibition of osteoblast maturation and ossification, downregulation of phosphorylated PI3K-AKT, and impaired Notch signaling during bone fracture union. These findings indicated that Piezo1 protein is a potential target for enhancing bone regeneration and treating delayed or nonunion bone fractures.
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