Cyclopolymerization of Diallylamine and its Condensation with Carboxylic Drugs

In this study, the polydiallylamine (P1) was prepared by free radical cyclopolymerization then the three new drug carriers cyclopolymers (P2-P4) were prepared according to substitution polymer P1 to its amine of prepared diallylamine polymer P1 to its corresponding N-drug through amide attachments such as N-Ibuprofine, ciprofloxacin and mefenamic acyl chloride, which formed amide bonds. This can be hydrolysed in different pH values at 37oC, as controlled drug release to obtain a sustained drug release. This can lead to improve their activities as a therapeutic material and to prevent any side effect of the drugs. The cyclopolymers (P1-P4) were characterized by Fourier Trans Infrared (FTIR), Proton Nuclear magnetic resonance 1H-NMR and UV-Vis spectroscopies. Additionally, intrinsic viscosity was measured and all physical properties were measured.