Layer‐by‐Layer Encapsulation of Probiotics for Delivery to the Microbiome

Advanced MaterialsVolume 28, Issue 43 p. 9486-9490 Communication Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome Aaron C. Anselmo, Aaron C. Anselmo David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USASearch for more papers by this authorKevin J. McHugh, Kevin J. McHugh David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USASearch for more papers by this authorJamie Webster, Jamie Webster David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USASearch for more papers by this authorRobert Langer, Corresponding Author Robert Langer rlanger@mit.edu David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USAE-mail: rlanger@mit.edu, jaklenec@mit.eduSearch for more papers by this authorAna Jaklenec, Corresponding Author Ana Jaklenec jaklenec@mit.edu David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USAE-mail: rlanger@mit.edu, jaklenec@mit.eduSearch for more papers by this author Aaron C. Anselmo, Aaron C. Anselmo David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USASearch for more papers by this authorKevin J. McHugh, Kevin J. McHugh David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USASearch for more papers by this authorJamie Webster, Jamie Webster David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USASearch for more papers by this authorRobert Langer, Corresponding Author Robert Langer rlanger@mit.edu David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USAE-mail: rlanger@mit.edu, jaklenec@mit.eduSearch for more papers by this authorAna Jaklenec, Corresponding Author Ana Jaklenec jaklenec@mit.edu David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, MA, 02139 USAE-mail: rlanger@mit.edu, jaklenec@mit.eduSearch for more papers by this author First published: 12 September 2016 https://doi.org/10.1002/adma.201603270Citations: 157Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract The gastrointestinal (GI) microbiome is widely investigated for its role in many diseases. However, technologies designed for microbiome delivery are lacking. Here, a layer-by-layer (LbL) approach is reported for probiotic encapsulation to protect probiotics against GI tract insults and improve their adhesion and growth on the intestines. These advantages translate to significantly enhanced survival of LbL-probiotics in vivo. Citing Literature Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Filename Description adma201603270-sup-0001-S1.pdf1.3 MB Supplementary Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. Volume28, Issue43November 16, 2016Pages 9486-9490 RelatedInformation