Early- vs late-start levodopa relieved symptoms but did not affect disease progression in Parkinson disease

ACP Journal Club21 May 2019Early- vs late-start levodopa relieved symptoms but did not affect disease progression in Parkinson diseaseJoseph H. Friedman, MDJoseph H. Friedman, MDButler Hospital/Alpert Medical School of Brown University, Providence, Rhode Island, USA. (J.H.F.)Author, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJ201905210-056 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationVerschuur CVM, Suwijn SR, Boel JA, et al; LEAP Study Group. Randomized delayed-start trial of levodopa in Parkinson's disease. N Engl J Med. 2019;380:315-24. https://pubmed.ncbi.nlm.nih.gov/30673543Clinical Impact RatingsGIM/FP/GP: Neurology: References1 Fahn S, Oakes D, Shoulson I, et al; Parkinson Study Group. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004;351:2498-508. [PMID: 15590952] Google Scholar2 Espay AJ, Morgante F, Merola A, et al. Levodopa-induced dyskinesia in Parkinson disease: current and evolving concepts. Ann Neurol. 2018;84:797-811. [PMID: 30357892] Google Scholar Author, Article, and Disclosure InformationAffiliations: Butler Hospital/Alpert Medical School of Brown University, Providence, Rhode Island, USA. (J.H.F.)This article was published at Annals.org on 7 May 2019. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDrp1-mediated mitochondrial fission contributes to mitophagy in paraquat-induced neuronal cell damage 21 May 2019Volume 170, Issue 10Page: JC56KeywordsDisabilitiesDopamineDrugsIntent to treat analysisLevodopaLife expectancyNeurologyOxidative stressParkinson disease ePublished: 21 May 2019 Issue Published: 21 May 2019 Copyright & PermissionsCopyright © 2019 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...