荧光
线粒体
部分
代谢物
半胱氨酸
化学
新陈代谢
生物物理学
香豆素
生物化学
双键
生物
立体化学
酶
有机化学
量子力学
物理
作者
Xiaopeng Yang,Wenya Liu,Jun Tang,Ping Li,Haibo Weng,Yong Ye,Ming Xian,Bo Tang,Yufen Zhao
摘要
In this study, we developed a multi-signal mitochondria-targeted fluorescent probe (NIR-Cys) for simultaneous detection of Cys and its metabolite, SO2. In the design of the probe, the acrylate group and the C[double bond, length as m-dash]C of the coumarin ring were used as the recognizing moiety for Cys and SO2, respectively. The probe exhibited high sensitivity, excellent specificity, and fast response. NIR-Cys was found to precisely target and visualize Cys metabolism in mitochondria of living cells with a multi-fluorescence signal. This probe is expected to be a useful tool for understanding Cys metabolism.
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