무궁화나무(Hibiscus syriacus) 수피 추출물의 페놀산 조성 및 기능성화장품 소재 가능성 평가

The purpose of this study was to investigate the phenolic acid contents and compositions, and possibility of functional cosmetic ingredients of Hibiscus syriacus bark extracts with hot water and 70% ethanol solution. The results were as follows: Total polyphenol and total flavonoid content, hot water extract was grater than 70% ethanol extract. Regarding the composition of polyphenol compound, 8 different types of phenolic acids and 4 different types of flavonoids were found in hot-water and 70% ethanol extracts. In terms of DPPH radical scavenging activity, water extract was about 2 times grater than 70% ethanol extract. Nitrite-scavenging activity against hot water extract was 52.30 ± 0.42% and for the 70% ethanol extract was 46.00 ± 0.52% of stem bark in pH 1.2, respectively. In the tyrosinase inhibition activity of IC50, hot water extract was about 1.6 times grater than 70% ethanol extract. Bacterium cell growth was inhibited the proportional to the concentration for both the hot water and 70% ethanol extracts of bark for the Gram-negative E. coli KCCM 11234 bacterium. Cytotoxicity for SK-MEL-2 cell line was not appeared for hot water, and appeared about 16% in the 100 μg for 70% ethanol extract.