4-(6,7-Dihydro-5H-indeno[5,6-d] thiazol-2-yl)benzene-1,3-diol prevents UV-induced melanogenesis and wrinkle formation in HRM-2 hairless mice

Chronic sun exposure is believed to be the most significant factor in skin aging and approximately 80% of facial aging is considered to be the result of chronic sun exposure [ [1] Flament F. Bazin R. Laquieze S. Rubert V. Simonpietri E. Piot B: effect of the sun on visible clinical signs of aging in caucasian skin. Clin. Cosmet. Investig. Dermatol. 2013; 6: 221-232 Crossref PubMed Scopus (120) Google Scholar ]. Increased melanogenesis in response to ultraviolet (UV) exposure is to protect skin cells and tissue structure from damage [ [2] Brenner M. Hearing V.J. Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents. Drug Discov. Today Dis. Mech. 2008; 5: e189-e199 Crossref PubMed Scopus (74) Google Scholar ]. However, repeated exposure of UV light causes hyperpigmentation of skin resulting in lentigines solares and melasma [ [2] Brenner M. Hearing V.J. Modifying skin pigmentation – approaches through intrinsic biochemistry and exogenous agents. Drug Discov. Today Dis. Mech. 2008; 5: e189-e199 Crossref PubMed Scopus (74) Google Scholar ]. In addition, although it is unclear whether cutaneous wrinkles are caused by loss of fibrillar collagens or loss of elastic fiber components [ [3] Watson R.E. Griffiths C.E. Craven N.M. Shuttleworth C.A. Kielty C.M. Fibrillin-rich microfibrils are reduced in photoaged skin. Distribution at the dermal-epidermal junction. J. Investig. Dermatol. 1999; 112: 782-787 Abstract Full Text Full Text PDF PubMed Scopus (150) Google Scholar ], preventing UV-induced skin inflammation is beneficial for inhibiting wrinkle formation.