化学
MCF-7型
姜黄素
透明质酸
多西紫杉醇
药物输送
乳腺癌
癌细胞
细胞生长
细胞培养
癌症研究
药品
药理学
癌症
生物化学
内科学
医学
生物
人体乳房
有机化学
遗传学
解剖
作者
Luca Paoletti,Nicole Zoratto,Monica Benvenuto,Daniela Nardozi,Valentina Angiolini,Patrizia Mancini,Laura Masuelli,Bei R,Giovanni Vanni Frajese,Pietro Matricardi,M. Nalli,Chiara Di Meo
标识
DOI:10.1016/j.carbpol.2023.120900
摘要
An innovative hyaluronan-based nano-delivery system is proposed for the active targeting towards ER+ breast cancer. Hyaluronic acid (HA), an endogenous and bioactive anionic polysaccharide, is functionalized with estradiol (ES), a sexual hormone involved in the development of some hormone-dependent tumors, to give an amphiphilic derivative (HA-ES) able to spontaneously self-assemble in water to form soft nanoparticles or nanogels (NHs). The synthetic strategy used to obtain the polymer derivatives and the physico-chemical properties of the obtained nanogels (ES-NHs) are reported. ES-NHs ability to entrap hydrophobic molecules has also been investigated, by loading curcumin (CUR) and docetaxel (DTX), both able to inhibit the growth of ER+ breast cancer. The formulations are studied for their capability to inhibit the growth of the MCF-7 cell line, thus evaluating their efficacy and potential as a selective drug delivery systems. Our results demonstrate that ES-NHs have not toxic effects on the cell line, and that both ES-NHs/CUR and ES-NHs/DTX treatments inhibit MCF-7 cell growth, with ES-NHs/DTX effect higher than that of free DTX. Our findings support the use of ES-NHs to deliver drugs to ER+ breast cancer cells, assuming a receptor-dependent targeting.
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