化学
环闭合复分解
烯烃
分子内力
埃尼
戒指(化学)
氢原子
自由基环化
恩尼复分解
组合化学
复分解
立体化学
有机化学
催化作用
聚合
聚合物
烷基
作者
Wanting Li,Zhixia Zhang,Jing Huang,Huimin Jiang,Zhen-Wei Luo,Jin‐Heng Li,Xuan‐Hui Ouyang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2024-07-30
卷期号:26 (31): 6664-6669
标识
DOI:10.1021/acs.orglett.4c02332
摘要
A photocatalytic method for the ring-closing 1,7-enyne metathesis using the α-amino radical as an alkene deconstruction auxiliary is present. Preliminary mechanistic studies suggest that intramolecular 1,5-hydrogen atom transfer is the key to the generation and β-scission of the α-amino radical, while the dearomatization of arenes and ring opening of cyclopropanes are the key to construct spirocyclic quinolin-2-ones. This approach highlights the potential of ring-closing 1,7-enyne metathesis, providing a green, efficient, and step-economical way for the synthesis of spirocyclic quinolin-2-ones.
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