脂肪酶
生物催化
手性(物理)
超分子化学
催化作用
超分子手性
材料科学
纳米技术
组合化学
化学
有机化学
酶
分子
反应机理
夸克
Nambu–Jona Lasinio模型
手征对称破缺
量子力学
物理
作者
Meng Sun,Yuyang Wang,An‐Ni Huang,Hanlu Wang,Shiqiao Peng,Fengli Gao,Jing Wang,Xinqiang Song,Chuanliang Feng
标识
DOI:10.1021/acsami.4c10295
摘要
How to maintain high catalytic activity and stability in the process of biocatalysis is crucial, inspiring strategies to construct an appropriate catalytic microenvironment. Considering the lipase's inherent chirality and the necessity for a delicate hydrophilic–hydrophobic equilibrium, we crafted a chiral, nonaqueous catalytic microenvironment via the in situ coassembly of Boc-FLFL-NHNH2 (Bfl) and lipase. Benefiting from the chirality and distinct Bfl–lipase interactions, the lipase@Bfl supramolecular hybrid amplifies biological functionalities and can serve as a versatile and highly efficient catalyst. Kinetic investigations and molecular docking simulations uncover the strong lipase-substrate affinity and lipase–Bfl interactions, explaining the enhanced biological effects, catalytic activity, and stability. Our study establishes a suitable microenvironment to address the chirality and hydrophobicity during catalysis and highlights the potential of artificial chiral scaffolds and catalytic medium for enhancing lipase activity.
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