前中期
减数分裂
生物
非整倍体
染色体
染色体分离
中期
遗传学
体细胞
不分离
细胞生物学
核型
基因
作者
Osamu Takenouchi,Yogo Sakakibara,Tomoya S. Kitajima
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2024-07-18
卷期号:385 (6706)
被引量:1
标识
DOI:10.1126/science.adn5529
摘要
Meiotic errors of relatively small chromosomes in oocytes result in egg aneuploidies that cause miscarriages and congenital diseases. Unlike somatic cells, which preferentially mis-segregate larger chromosomes, aged oocytes preferentially mis-segregate smaller chromosomes through unclear processes. Here, we provide a comprehensive three-dimensional chromosome identifying-and-tracking dataset throughout meiosis I in live mouse oocytes. This analysis reveals a prometaphase pathway that actively moves smaller chromosomes to the inner region of the metaphase plate. In the inner region, chromosomes are pulled by stronger bipolar microtubule forces, which facilitates premature chromosome separation, a major cause of segregation errors in aged oocytes. This study reveals a spatial pathway that facilitates aneuploidy of small chromosomes preferentially in aged eggs and implicates the role of the M phase in creating a chromosome size–based spatial arrangement.
科研通智能强力驱动
Strongly Powered by AbleSci AI