炎症体
听力损失
听力学
C57BL/6型
内分泌学
医学
神经科学
内科学
心理学
炎症
作者
Jinlan Liu,Yongfeng Si,Xiaoying Huang,Xinran Lin,LU Ling-juan,Chang‐Lin Wu,Xuan Guan,Yunsheng Liang
标识
DOI:10.1016/j.neulet.2024.137897
摘要
The efficacy of vitamin C in age-related hearing loss, i.e., presbycusis, remains debatable. On a separate note, inflammation induced by the NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome is involved in the progression of presbycusis. In this study, we investigated the effect of vitamin C on male C57BL/6 mice's presbycusis and NLRP3 inflammasome. The results showed that vitamin C treatment improved hearing, reduced the production of inflammatory factors, inhibited NLRP3 inflammasome activation, and decreased cytosolic mitochondrial DNA (mtDNA) in the C57BL/6 mouse cochlea, inferior colliculus, and auditory cortex. According to this study, vitamin C protects auditory function in male C57BL/6 presbycusis mice through reducing mtDNA release, inhibiting the NLRP3 inflammasome activation in the auditory pathway. Our study provides a theoretical basis for applying vitamin C to treat presbycusis.
科研通智能强力驱动
Strongly Powered by AbleSci AI