化学
分子内力
催化作用
铜
氧化磷酸化
组合化学
有机化学
药物化学
光化学
生物化学
作者
Haojie Ma,Fengyuan Zhou,Yuqi Li,Yuqi Zhang,Guosheng Huang,Xing Yang,Ji‐Jiang Wang
标识
DOI:10.1002/adsc.202400493
摘要
The synthesis of substituted 2‐hydroxy‐indolin‐3‐ones has attracted considerable attention due to the frequent presence of the indole nucleus in numerous natural products and biologically active molecules. Herein, a direct access to 2‐hydroxy‐indolin‐3‐ones through copper‐catalyzed oxidative intramolecular cyclization of N‐(2‐acetylphenyl)picolinamide has been developed. This method exhibits good functional group tolerance, atom‐economy and avoids the pre‐functionalization of substrates.
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