IEG expression defines SST neuron ensembles critical for motor learning

Neocortical interneurons have been hypothesized to be important for circuit reorganization during learning. In this issue of Neuron, Yang et al., 2022 Yang J. Serrano P. Yin X. Sun X. Lin Y. Chen S.X. Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning. Neuron. 2022; 110: 3339-3355https://doi.org/10.1016/j.neuron.2022.08.018 Abstract Full Text Full Text PDF Scopus (2) Google Scholar identify a subset of Npas4-expressing somatostatin interneurons that help regulate excitatory synaptic plasticity during motor learning. Neocortical interneurons have been hypothesized to be important for circuit reorganization during learning. In this issue of Neuron, Yang et al., 2022 Yang J. Serrano P. Yin X. Sun X. Lin Y. Chen S.X. Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learning. Neuron. 2022; 110: 3339-3355https://doi.org/10.1016/j.neuron.2022.08.018 Abstract Full Text Full Text PDF Scopus (2) Google Scholar identify a subset of Npas4-expressing somatostatin interneurons that help regulate excitatory synaptic plasticity during motor learning. Functionally distinct NPAS4-expressing somatostatin interneuron ensembles critical for motor skill learningYang et al.NeuronSeptember 12, 2022In BriefUtilizing in vivo two-photon imaging in behaving mice, Yang et al. reveal that motor learning triggers an emergence of an NPAS4-expressing SST-IN ensemble that regulates the spine remodeling of downstream PNs through disinhibition. Moreover, NPAS4 re-expression is critical in maintaining the functionally distinct SST-IN ensemble throughout the course of learning. Full-Text PDF