单宁酸
肉芽组织
伤口愈合
聚乙烯醇
生物相容性
自愈水凝胶
抗菌剂
化学
抗菌活性
核化学
药理学
生物医学工程
材料科学
医学
外科
高分子化学
细菌
有机化学
生物
遗传学
作者
Meiqi Cheng,Le Hu,Gan Xu,Panpan Pan,Qing Liu,Ziyue Zhang,Zhanpeng He,Chunxiao Wang,Man Liu,Li Chen,Jingdi Chen
标识
DOI:10.1016/j.colsurfb.2023.113354
摘要
The clinical treatment of infected skin injuries caused by exogenous bacteria faces great challenges. Conventional therapeutic approaches are difficult to achieve synergistic effects of infection control and induction of skin regeneration. In this study, a novel tannic acid-based physically cross-linked double network hydrogel (PDH gel) was prepared on demand by covalent cross-linking of tannic acid (TA) with polyvinyl alcohol (PVA) and chelating ligand of TA with Fe3+. The homogeneity of the hydrogel was achieved by the action of glycol dispersant. With the anti-inflammatory and antioxidant properties of Fe3+ and TA, this hydrogel exhibited excellent antibacterial properties by achieving 99.69% and 99.36% bacterial inhibition against E.coli and S. aureus, respectively. Moreover, the PDH gel exhibits good biocompatibility, stretchability (up to 200%) and skin-friendliness. After 14 days of PDH-1 gel implantation in a rat model infected by S. aureus, the wound healing rate was as high as 95.21%. PDH gel-1 showed more granulation tissue, more pronounced blood vessels, higher collagen fiber density and good collagen deposition, and its recovery effect was better than that of PSH gel and PDH gel-2 in vivo. Hence, this study provides a novel avenue for the design of future clinical infected wound healing dressings.
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