Proteomics Landscape Mapping of Organ‐Resolved Behçet's Disease Using In‐Depth Plasma Proteomics for Identifying Hyaluronic Binding Protein 2 Expression Associated With Vascular Involvement

发病机制 蛋白质组学 血管生成 医学 蛋白质组 定量蛋白质组学 生物标志物 生物信息学 免疫学 生物 癌症研究 基因 遗传学
作者
Linlin Cheng,Dongxue Wang,Zhimian Wang,Haolong Li,Guibin Wang,Ziyan Wu,Meng Xu,Songxin Yan,Haoting Zhan,Hongye Wang,Xiaomei Zhang,Te Liang,Chundi Wei,Fengchun Zhang,Wenjie Zheng,Xiaobo Yu,Yongzhe Li
出处
期刊:Arthritis & rheumatology [Wiley]
卷期号:75 (3): 424-437 被引量:6
标识
DOI:10.1002/art.42348
摘要

This study was undertaken to elucidate the pathogenesis and heterogeneity of Behçet's disease (BD) involving different organs using in-depth proteomics to identify the biomarkers for clinical assessment and treatment of patients with BD.We measured the expression levels of proteins in plasma samples from 98 patients with BD and from 31 healthy controls using our in-depth proteomics platform with a data-independent acquisition mass spectrometer and antibody microarray. We performed bioinformatics analyses of the biologic processes and signaling pathways that were changed in the BD group and constructed a proteomics landscape of organ-resolved BD pathogenesis. We then validated the biomarkers of disease severity and the vascular subset in an independent cohort of 108 BD patients and 29 healthy controls using an enzyme-linked immunosorbent assay.The BD group had 220 differentially expressed proteins, which discriminated between BD patients (88.6%) and healthy controls (95.5%). The bioinformatics analyses revealed different biologic processes associated with BD pathogeneses, including complement activation, wound healing, angiogenesis, and leukocyte-mediated immunity. Furthermore, the constructed proteomics landscape of organ-resolved BD identified proteomics features of BD associated with different organs and protein targets that could be used for the development of therapeutic treatment. Hyaluronic binding protein 2, tenascin, and serpin A3 were validated as potential biomarkers for the clinical assessment of vascular BD and treatment targets.Our results provide valuable insight into the pathogenesis of organ-resolved BD in terms of proteomics characteristics and potential biomarkers for clinical assessment and potential therapies for vascular BD.
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