Fabrication of a Fast Response Non-Enzymatic Glucose Sensor Based on In-Situ Synthesized of Cu-Metal Organic Frameworks Integrated with Electrochemically Reduced Graphene Quantum Dots

During this study, a novel and fast response platform based on in-situ synthesized of Cu-metal organic frameworks (Cu-MOFs) integrated with electrochemically reduced graphene quantum dots (ErGQDs) was developed through electrochemical deposition method and conversation process. Accordingly, in the first step, metallic copper and ErGQDs were simultaneous electrochemically deposited on the surface of carbon ceramic electrode (CCE). Then, metallic copper was converted to copper oxide by cyclic voltammetry technique. Finally by adding benzene-1, 3, 5-tricarboxylic acid (BTC), copper based MOFs (copper-benzene-1, 3, 5-tricarboxylic acid) formed on the surface of constructed electrode by a fast in-situ conversation process and the fabricated electrode (Cu-MOFs/ErGQDs/CCE), was used for the non-enzymatic electrochemical detection of glucose. The physicochemical characterization and electrocatalytic behavior of fabricated electrode toward glucose oxidation were studied through the suitable techniques. The electrochemical results demonstrated that the Cu-MOFs/ErGQDs/CCE is a suitable loading platform which exhibits wide linear ranges of 2.0-500.0 µM, detection limit of 0.59 µM (S/N = 3), high sensitivity (5069 μA cm-2 mM-1), selectivity, stability and reproducibility for electrochemical detection of glucose. Finally, the present sensor was used for accurate and precise detection of glucose in human blood serum and saliva samples.