When chronic kidney disease (CKD) intersects with heart failure: Insights and implications of the identification of KDIGO‐defined CKD in 1.4 million U.S. Veterans with heart failure

European Journal of Heart FailureEarly View Invited Editorial When chronic kidney disease (CKD) intersects with heart failure: Insights and implications of the identification of KDIGO-defined CKD in 1.4 million U.S. Veterans with heart failure Bertram Pitt, Corresponding Author Bertram Pitt [email protected] University of Michigan School of Medicine, Ann Arbor, MI, USA Corresponding author. University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0366, USA. Email: [email protected]Search for more papers by this authorPatrick Rossignol, Patrick Rossignol Université de Lorraine, Centre d'Investigations Cliniques Plurithématique 14-33, Inserm U1116, CHRU Nancy, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France Medicine Specialties and Nephrology-Dialysis Departments, Princess Grace Hospital, and Monaco Private Hemodialysis Centre, Monaco City, MonacoSearch for more papers by this author Bertram Pitt, Corresponding Author Bertram Pitt [email protected] University of Michigan School of Medicine, Ann Arbor, MI, USA Corresponding author. University of Michigan School of Medicine, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0366, USA. Email: [email protected]Search for more papers by this authorPatrick Rossignol, Patrick Rossignol Université de Lorraine, Centre d'Investigations Cliniques Plurithématique 14-33, Inserm U1116, CHRU Nancy, and F-CRIN INI-CRCT (Cardiovascular and Renal Clinical Trialists), Nancy, France Medicine Specialties and Nephrology-Dialysis Departments, Princess Grace Hospital, and Monaco Private Hemodialysis Centre, Monaco City, MonacoSearch for more papers by this author First published: 10 June 2024 https://doi.org/10.1002/ejhf.3298 The opinions expressed in this article are not necessarily those of the Editors of the European Journal of Heart Failure or of the European Society of Cardiology. doi: 10.1002/ejhf.3210. Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat No abstract is available for this article. References 1Zannad F, Rossignol P. Cardiorenal syndrome revisited. Circulation 2018; 138: 929–944. https://doi.org/10.1161/CIRCULATIONAHA.117.028814 10.1161/CIRCULATIONAHA.117.028814 PubMedWeb of Science®Google Scholar 2Zoccali C, Mallamaci F, Halimi JM, Rossignol P, Sarafidis P, De Caterina R, et al. Chronic cardiovascular-kidney disorder: A new conceptual framework. Nat Rev Nephrol 2024; 20: 201–202. https://doi.org/10.1038/s41581-023-00789-8 10.1038/s41581-023-00789-8 PubMedWeb of Science®Google Scholar 3Damman K, Valente MA, Voors AA, O'Connor CM, van Veldhuisen DJ, Hillege HL. Renal impairment, worsening renal function, and outcome in patients with heart failure: An updated meta-analysis. Eur Heart J 2014; 35: 455–469. https://doi.org/10.1093/eurheartj/eht386 10.1093/eurheartj/eht386 PubMedWeb of Science®Google Scholar 4Patel S, K. Raman KV, Zhang S, Deedwania P, Zeng-Treitler Q, Wu WC, et al. Identification and outcomes of KDIGO-defined chronic kidney disease in 1.4 million U.S. Veterans with heart failure. Eur J Heart Fail. https://doi.org/10.1002/ejhf.3210 Published online ahead of print 03/05/24. 10.1002/ejhf.3210 Web of Science®Google Scholar 5Levin A, Ahmed SB, Carrero JJ, Foster B, Francis A, Hall RK, et al. Executive summary of the KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease: Known knowns and known unknowns. Kidney Int 2024; 105: 684–701. https://doi.org/10.1016/j.kint.2023.10.016 10.1016/j.kint.2023.10.016 PubMedWeb of Science®Google Scholar 6Legrand M, Rossignol P. Cardiovascular consequences of acute kidney injury. N Engl J Med 2020; 382: 2238–2247. https://doi.org/10.1056/NEJMra1916393 10.1056/NEJMra1916393 CASPubMedWeb of Science®Google Scholar 7Rossignol P, Hernandez AF, Solomon SD, Zannad F. Heart failure drug treatment. Lancet 2019; 393: 1034–1044. https://doi.org/10.1016/S0140-6736(18)31808-7 10.1016/S0140-6736(18)31808-7 CASPubMedWeb of Science®Google Scholar 8Agarwal R, Fouque D. The foundation and the four pillars of treatment for cardiorenal protection in people with chronic renal disease and type 2 diabetes. Nephrol Dial Transplant 2023; 38: 253–257. https://doi.org/10.1093/ndt/gfac331 10.1093/ndt/gfac331 CASPubMedWeb of Science®Google Scholar 9Ronco C, Haapio M, House AA, Anavekar N, Bellomo R. Cardiorenal syndrome. J Am Coll Cardiol 2008; 52: 1527–1539. https://doi.org/10.1016/j.jacc.2008.07.051 10.1016/j.jacc.2008.07.051 PubMedWeb of Science®Google Scholar 10Ndumele CE, Rangaswami J, Chow SL, Neeland IJ, Tuttle KR, Khan SS, et al. Cardiovascular-kidney-metabolic health: A presidential advisory from the American Heart Association. Circulation 2023; 148: 1606–1635. https://doi.org/10.1161/CIR.0000000000001184 10.1161/CIR.0000000000001184 PubMedWeb of Science®Google Scholar 11Andersen K, Kesper MS, Marchner JA, Konrad L, Ryu M, Kumar VS, et al. Intestinal dysbiois, barrier dysfunction and bacterial translocation account for CKD-related systemic inflammation. J Am Soc Nephrol 2017; 28: 76–83. https://doi.org/10.1681/ASN.2015111285 10.1681/ASN.2015111285 CASPubMedWeb of Science®Google Scholar 12Ray A, Stelloh C, Liu Y, Meyer A, Geurts AM, Cowley AW Jr, et al. Histone modifications and their contributions to hypertension. Hypertension 2024; 81: 229–239. https://doi.org/10.1161/HYPERTENSIONAHA.123.21755 10.1161/HYPERTENSIONAHA.123.21755 CASPubMedWeb of Science®Google Scholar 13Tang PCT, Zang YZ, Chan MKK, Lam WW, Chung JY, Kang W, et al. The emerging role of innate Immuinity in chronic kidney disease. Int J Mol Sci 2020; 21:4018. https://doi.org/10.3390/ijms21114018 10.3390/ijms21114018 CASPubMedWeb of Science®Google Scholar 14Parksook WW, Brown JM, Omata K, Tezuka Y, Ono Y, Satoh F, et al. The spectrum of dysregulated aldosterone production: An international human physiology study. J Clin Endocrinol Metab 2024; dgae145. https://doi.org/10.1210/clinem/dgae145 10.1210/clinem/dgae145 Web of Science®Google Scholar Early ViewOnline Version of Record before inclusion in an issue ReferencesRelatedInformation